In 2004, she recorded her first single, "Shake Ya Body", which had a music video featuring contestants from cycle 2 of America's Next Top Model. Banks held a casting call to find faces for her line, eventually selecting Melody Parra, Monique Hayward, Katy Harvey and Top Model Norge contestant Marita Gomsrud as the cosmetic line's original beauty models.In 2013, Banks transformed herself into 15 supermodels, in collaboration with fashion photographer Udo Spreitzenbarth.In 2005, when asked about her relationship history, she stated, "I won't be using a lot of names on the show, but a specific relationship had not just cheating but emotional abuse.It was really bad, but that made me strong." In 2009, she opened up about her past relationships when she made a guest appearance on The Oprah Winfrey Show, hosting alongside Oprah Winfrey.Banks has said that while growing up she was teased for her appearance and considered an "ugly duckling"; When Banks was 15 years old, she started modeling while attending school in Los Angeles. In her first runway season, she booked 25 shows in the 1991 Paris Fashion Week.
In 2017, Banks replaced Nick Cannon as host of America's Got Talent for its 12th season.
She remained executive producer for the revival of the series, and enlisted Rita Ora as host for the twenty-third cycle before reassuming the duties herself for the upcoming twenty-fourth cycle.
Banks was the co-creator of True Beauty, and had her own talk show, The Tyra Banks Show, which aired on The CW for five seasons and won two Daytime Emmy awards for Outstanding Talk Show Informative.
She was a Victoria's Secret Angel from 1997 to 2005.
By the early 2000s, Banks was one of the world's top-earning models.